Dioplus Tablets Specification

Name: Dioplus Tablets 5/80Mg (1 Box = 2 Strips) (1 Strip = 7 Tablets)
Brand: Taabib.com
Price: 415.0 PKR
Availability: InStock

Requires Prescription (YES/NO)

Yes

Generics

Amlodipine Besilate + Valsartan

Used For

Hypertension

How it works

Amlodipine and Valsartan are antihypertensive compounds with complementary mechanisms to control blood pressure in patients with essential hypertension. The combination of these substances has an additive antihypertensive effect, reducing blood pressure to a greater degree than either component alone.

Dioplus Tablets Usage And Safety

Dosage

Amlodipine Besilate + Valsartan

Side Effects

Nasopharyngitis, influenza, hypokalemia, headache, asthenia, fatigue, facial edema, flushing, hot flush, edema, edema peripheral and pitting edema , Anorexia, hypercalcemia, hyperlipidemia, hyperuricemia, hyponatremia, coordination abnormal, dizziness, dizziness postural, paraesthesia, somnolence, visual impairment, vertigo, palpitations, tachycardia, orthostatic hypotension, cough, pharyngolaryngeal pain, abdominal discomfort, abdominal pain upper, constipation, diarrhea, dry mouth, nausea, erythema, rash, arthralgia, back pain and joint swelling.

Drug Interactions

Antihypertensive agents , grapefruit or grapefruit juice , CYP3A4 inhibitors (protease inhibitors, azole antifungals, macrolides like erythromycin or clarithromycin, verapamil or diltiazem) , CYP3A4 inducers (e.g. rifampicin, Hypericum perforatum) , Simvastatin , Lithium , Potassium-sparing diuretics, potassium supplements, salt substitutes containing potassium , NSAIDs , (rifampicin, cyclosporine) or efflux transporter (ritonavir) , Sildenafil.

Indication

It is indicated for the treatment of Hypertension.

When not to Use

The combination of amlodipine and valsartan is contraindicated in: - Patients with known hypersensitivity to the active substances, to dihydropyridine derivatives or to any of the excipient of the product. Severe hepatic impairment, biliary cirrhosis or cholestasis.

Dioplus Tablets Precautions

Precaution

Combination of amlodipine + valsartan should be used with caution to treat hypertension in patients with unilateral or bilateral renal artery stenosis or stenosis to a solitary kidney since blood urea and serum creatinine may increase in such patients.

Dioplus Tablets Warnings

Warning 1

Concomitant use with potassium supplements, potassium-sparing diuretics, salt substitutes containing potassium, or other medicinal products that may increase potassium levels (heparin, etc.) should be undertaken with caution and with frequent monitoring of potassium levels.

Warning 2

The safety and efficacy of amlodipine in hypertensive crisis have not been established.

Warning 3

Angioedema, including swelling of the larynx and glottis, causing airway obstruction and/or swelling of the face, lips, pharynx and/or tongue, has been reported in patients treated with valsartan. Combination of amlodipine + valsartan should be discontinued immediately in patients who develop angioedema and should not be re-administered.

Dioplus Tablets 5/80Mg (1 Box = 2 Strips) (1 Strip = 7 Tablets)