Co-Dorzal Eye Specification

Requires Prescription (YES/NO)

Yes

Generics

Dorzolamide HCl , Timolol Maleate

Used For

Glaucoma

How it works

It is the first combination of a topical carbonic anhydrase inhibitor and a topical beta-adrenergic receptor blocking agent

Co-Dorzal Eye Usage And Safety

Dosage

Dorzolamide HCl , Timolol Maleate

Side Effects

Ocular burning and stinging, taste perversion, corneal erosion, conjuning injection, blurred vision, tearing and ocular itching. Urolithiasis was reported rarely.

Drug Interactions

Dorzolamide & Timolol : ACE-inhibitors, calcium channel-blockers diuretics, non-steroidal anti-inflammatory drugs including aspirin, and hormones (e.g., estrogen, insulin, thyroxine).Timolol maleate : Oral calcium ,channel blockers, catecholamine-depleting drug or beta-adrenergic blocking agents. quinidine, SSRIs . Dorzolamide : Oral carbonic anhydrase inhibitors

Indication

It is indicated in the treatment of elevated intraocular pressure (IOP) in patients with ocular hypertension, open-angle glaucoma, pseudoexfoliative glaucoma or other secondary open-angle glaucoma when concomitant therapy is appropriate.

When not to Use

It is contraindicated in patients with: • Bronchial asthma or the history of bronchial asthma, or severe chronic obstructive pulmonary disease • Sinus bradycardia, second or third degree artrioventricular block, overt cardiac failure, cardiogenic shock • Hypersensitivity to any component of this product.

Co-Dorzal Eye Precautions

Precaution

Drug may be deposited in soft contact lenses; therefore, Dorzolamide/Timolol should not be administered while wearing these lenses, the lenses should be removed before application of the drops and should not bereinserted earlier than 15 minutes after use.

Co-Dorzal Eye Warnings

Warning 1

Because of timolol maleate component, cardiac failure should be adequately controlled before beginning therapy with this medicine in patients with a history of severe cardiac disease, signs of cardiac failure should be watched for and pulse rates should be checked.

Warning 2

Respiratory reactions and cardiac reactions, including death due to bronchospasm in patients with asthma and rarely death in association with cardiac failure, have been reported following administration of timolol maleate ophthalmic solution.

Warning 3

Dorzolamide/Timolol have not been studied in patients with severe renal impairment (CrCl < 30 milliliter/min). Because dorzolamide hydrochloride and its metabolite are excreted predominantly by the kidney, Dorzolamide/Timolol is not recommended in such patients.

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