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Aldactone-A Tablets 25Mg (1 Bottle = 100 Tablets)
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SKU
Aldactone-A Tablets Specification
Requires Prescription (YES/NO)
Yes
Generics
Spironolactone
Used For
Hypertension
How it works
It is a specific pharmacologic antagonist of aldosterone, acting primarily through competitive binding of receptors at the aldosterone-dependent, sodium-potassium exchange site in the distal convoluted renal tubule. It causes increased amounts of sodium and water to be excreted, while potassium loss is minimized. Spironolactone acts both as a diuretic and as an antihypertensive drug by this mechanism. It may be given alone or with other diuretic agents which act more proximally in the renal tubule.
Aldactone-A Tablets Usage And Safety
Dosage
Spironolactone
Side Effects
Blood and lymphatic system disorders: Leukopenia (including agranulocytosis), thrombocytopenia, anemia. Gastrointestinal disorders: Diarrhea and cramping, gastric bleeding, gastritis, nausea, ulceration, vomiting. General disorders and administration site conditions: Malaise. ATAXIA Hepatobiliary disorders: Abnormal hepatic function. A few cases of mixed spironolactone) cholestatic/hepatocellular toxicity, with one reported fatality, have been reported with spironolactone administration. Immune system disorders: Drug fever, urticaria, maculopapular or erythematous cutaneous eruptions, anaphylactic reactions, vasculitis, pruritus, rash. Metabolism and nutrition disorders: Electrolyte disturbances, hyperkalemia. Musculoskeletal and connective tissue disorders: Leg cramps, muscle spasms, rhabdomyolysis, myalgia, weakness Nervous system/psychiatric disorders: Mental confusion, ataxia, headache, drowsiness, lethargy, dizziness, change in libido. Renal and urinary disorders: Renal dysfunction (including acute renal failure). Reproductive system and breast disorders: gynecomastia, erectile dysfunction (inability to achieve or maintain erection), abnormal semen (decreased motility and sperm count), irregular menses or amenorrhea, postmenopausal bleeding, benign breast neoplasm, breast pain, breast carcinoma (including male patients).
Drug Interactions
Alcohol, barbiturates or narcotics , Antipyrine , Cholestyramine/ Ammonium Chloride , Corticosteroids, and adrenocorticotropic hormone (ACTH) , Diuretics and Antihypertensives , Eplerenone , Heparin, low molecular weight heparin , Drugs known to cause hyperkalemia , Lithium , Norepinephrine , Digoxin , Non-Steroidal Anti-Inflammatory Drugs .
Indication
It is used: • To treat essential hypertension (high blood pressure with an unknown cause) • To treat oedematous disorders (swelling with fluid), including congestive cardiac failure.
When not to Use
Do not take spironolactone if: • You are allergic to spironolactone or any of the other ingredients of this medicine • You cannot pass urine • You have severe kidney disease .
Aldactone-A Tablets Precautions
Precaution
It should be used with caution in patients with impaired hepatic function because minor alterations of fluid and electrolyte balance may precipitate hepatic coma.
Aldactone-A Tablets Warnings
Warning 1
Because of the diuretic action of spironolactone patients should be carefully evaluated for possible disturbance of fluid and electrolyte balance, due to the possibility of hyperkalemia, hypochloremic alkalosis, hyponatremia and possible blood urea nitrogen (BUN) elevation, especially the elderly and/or patients with pre-existing impaired renal or hepatic function.
Warning 2
Gynecomastia may develop with the use of spironolactone and physicians should be advised of its possible occurrence. The development of gynecomastia appears to be related to both dosage and duration of therapy and is normally reversible when the drug is discontinued. If gynecomastia develops, discontinue the drug. In rare instances some breast enlargement may persist.
Warning 3
Reversible hyperchloremic metabolic acidosis, usually in association with hyperkalemia, has been reported to occur in some patients with decompensated hepatic cirrhosis, even when renal function is normal. Caution should be used in treating patients with acute or severe liver impairments, since vigorous diuretic therapy may precipitate hepatic encephalopathy.
Aldactone-A Tablets Additional Information
Pregnancy category
Always consult your physician before using any medicine.
Storage (YES/NO)
Store this medicine at room temperature, away from direct light and heat.
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