Ryzodeg Penfill Specification

Name: Ryzodeg Penfill 100Iu/Ml
Brand: Taabib.com
Price: 11654.0 PKR
Availability: InStock

Requires Prescription (YES/NO)

Yes

Generics

Insulin degludec , Insulin Aspart

Used For

Diabetes Management

How it works

The primary activity of insulin, is regulation of glucose metabolism. Insulin and its analogs lower blood glucose by stimulating peripheral glucose uptake, especially by skeletal muscle and fat, and by inhibiting hepatic glucose production. Insulin also inhibits lipolysis and proteolysis, and enhances protein synthesis. The insulin degludec component in forms multi-hexamers when injected into the subcutaneous tissue resulting in a subcutanous insulin degludec depot. The protracted time action profile of RYZODEG 70/30 is predominantly due to delayed absorption of insulin degludec from the subcutaneous tissue to the systemic circulation and to a lesser extent due to binding of insulin-degludec to circulating albumin. Insulin aspart monomers are released rapidly into the circulation.

Ryzodeg Penfill Usage And Safety

Dosage

Insulin degludec , Insulin Aspart

Side Effects

Hypoglycemia , generalized skin reactions, angioedema, bronchospasm, hypotension, and shock , injection site reactions, including injection site hematoma, pain, hemorrhage, erythema, nodules, swelling, discoloration, pruritis, warmth, and injection site mass , Weight gain , Peripheral Edema .

Drug Interactions

Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, propoxyphene, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics, GLP-1 receptor agonists, DPP-4 inhibitors, SGLT-2 inhibitors. Atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), and thyroid hormones.

Indication

It is indicated to improve glycemic control in adults with diabetes mellitus.

When not to Use

It is contraindicated: • During episodes of hypoglycemia • In patients with hypersensitivity to or one of its excipients.

Ryzodeg Penfill Precautions

Precaution

These FlexTouch disposable prefilled pen should never be shared between patients, 228 even if the needle is changed. Sharing poses a risk for transmission of blood-borne pathogens.

Ryzodeg Penfill Warnings

Warning 1

Make any changes to a patient’s insulin regimen under close medical supervision with increased frequency of blood glucose monitoring. Advise patients who have repeatedly injected into areas of lipodystrophy or localized cutaneous amyloidosis to change the injection site to unaffected areas and closely monitor for hypoglycemia.

Warning 2

Hypoglycemia can happen suddenly and symptoms may differ in each individual and change over time in the same individual. Symptomatic awareness of hypoglycemia may be less pronounced in patients with longstanding diabetes, in patients with diabetic nerve disease, in patients using medications that block the sympathetic nervous system (e.g., beta-blockers) , or in patients who experience recurrent hypoglycemia.

Warning 3

All insulin products, including insulin degludec + insulin aspart, cause a shift in potassium from the extracellular to intracellular space, possibly leading to hypokalemia. Untreated hypokalemia may cause respiratory paralysis, ventricular arrhythmia, and death. Monitor potassium levels in patients at risk for hypokalemia if indicated (e.g., patients using potassium-lowering medications, patients taking medications sensitive to potassium concentrations).

Ryzodeg Penfill 100Iu/Ml